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Feeding the Finicky Feline

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Quimby J.M. Conference Proceedings, (2016). American College of Veterinary Internal Medicine, Denver:   IMPORTANCE OF NUTRITION Anorexia is one of the most common clinical signs of disease in cats presenting to the veterinary hospital. Unfortunately it is nonspecific and a … Read More

Dietary Links to Feline Hyperthyroidism

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Van Hoek I. Conference Proceedings, (2016). American College of Veterinary Internal Medicine, Denver:   CONCLUSION Epidemiological studies investigating environmental and nutritional exposures suggest HT to be a complex multifactorial disease. Diet and feeding canned food have been associated with HT … Read More

Update on Diagnostic and Therapeutic Applications for Radioisotopes in Veterinary Oncology

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Selting K. Conference Proceedings, (2016). American College of Veterinary Internal Medicine, Denver:   INTRODUCTION While some diagnostic and therapeutic applications of radioisotopes have become germane to routine specialty practice, such as technetium-based scintigraphy and radioiodine therapy, a rapidly expanding armamentarium … Read More

Evaluation of Quantitative Thyroid Scintigraphy for Diagnosis and Staging of Disease Severity in Cats with Hyperthyroidism: Comparison of the Percent Thyroidal Uptake of Pertechnetate to Thyroid-to-Salivary Ratio and Thyroid-to-Background Ratios

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Peterson M.E., Guterl J.N., Rishniw M., et al. Veterinary Radiology & Ultrasound, 2016. 57(4): p.427-440.   Thyroid scintigraphy is commonly used for evaluation of cats with hyperthyroidism, with the thyroid-to-salivary ratio (T/S) being the most common method to quantify the … Read More

Evaluation of Thyroid to Background Ratios and Comparison of Various Scintigraphic Measurements and Their Correlation to Serum T4 in Hyperthyroid Cats

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Bettencourt A., Daniel G.B., Panciera D., et al. Vet Radiol Ultrasound, 2016. 57(3): p.290-8.   Thyroid-to-salivary ratio and percent dose uptake are the most widely recognized scintigraphic measurements. Recently, the thyroid-to-background ratio has been proposed as an alternate method. However, … Read More

Prevalence and Degree of Thyroid Pathology in Hyperthyroid Cats Increases with Disease Duration: A Cross-Sectional Analysis of 2096 Cats Referred for Radioiodine Therapy

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Peterson M.E., Broome M.R. and Rishniw M. J Feline Med Surg, 2016. 18(2): p.92-103.   OBJECTIVES: Hyperthyroidism is common in cats, but there are no reports that evaluate its severity or underlying thyroid tumor disease based on disease duration (ie, … Read More

Abdominal Ultrasound Examination Findings in 534 Hyperthyroid Cats Referred for Radioiodine Treatment between 2007–2010

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Nussbaum L.K., Scavelli T.D., Scavelli D.M., et al. Journal of Veterinary Internal Medicine, 2015. 29(4): p.1069-1073.   Background The prevalence of concurrent disease in hyperthyroid cats is unknown. Objectives To identify the prevalence of concurrent intra-abdominal disease using abdominal ultrasound … Read More

Efficacy of Low-Dose (2 Millicurie) Versus Standard-Dose (4 Millicurie) Radioiodine (131I) Treatment for Cats with Mild-to-Moderate Hyperthyroidism

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Lucy J., Peterson M., Randolph J.F., et al. (2015). ACVIM Forum. Indianapolis, Indiana: 563.   Radioiodine (131I) is an effective treatment for feline hyperthyroidism, but optimal dosing to restore euthyroidism without inducing hypothyroidism remains unclear. Post-treatment hypothyroidism can lead to … Read More

Evaluation of Polybrominated Diphenyl Ethers (PBDEs) in Matched Cat Sera and House Dust Samples: Investigation of a Potential Link between Pbdes and Spontaneous Feline Hyperthyroidism

Chow K., Hearn L.K., Zuber M., et al. Environmental Research, 2015. 136(0): p.173-179.   The cause of feline hyperthyroidism (FH), a common endocrinopathy of domestic cats, is unknown. A potential association between exposure to environmental contaminants polybrominated diphenyl ethers (PBDEs) … Read More

The Effect of Methimazole Treatment for Feline Hyperthyroidism on the CT Appearance of the Thyroid Glands in Cats.

Bush J.L., Nemanic S. and Gordon J.   Conference Proceedings, (2014). American College of Veterinary Radiology:    Introduction/Purpose: Hyperthyroidism is diagnosed based on clinical signs and elevated serum total thyroxine (TT4) levels. Imaging diagnosis is made with nuclear scintigraphy, and … Read More

Prevalence of Disorders Recorded in Cats Attending Primary-Care Veterinary Practices in England

O’Neill D.G., Church D.B., Mcgreevy P.D., et al. Vet J, 2014.    Improved understanding of absolute and relative prevalence values for common feline disorders could support clinicians when listing differential diagnoses and also assist prioritisation of breeding, research and health … Read More

Feline Hyperthyroidism Reported in Primary-Care Veterinary Practices in England: Prevalence, Associated Factors and Spatial Distribution

Stephens M.J., Neill D.G., Church D.B., et al. Vet Rec, 2014.    Feline hyperthyroidism is a commonly diagnosed endocrinopathy that can have a substantial deleterious impact on the welfare of affected cats. This study aimed to estimate the prevalence, associated … Read More

The Effect of Chinese Rhubarb, Rheum Officinale, with and without Benazepril on the Progression of Naturally Occurring Chronic Kidney Disease in Cats

Hanzlicek A.S., Roof C.J., Sanderson M.W., et al.   J Vet Intern Med, 2014. 28(4): p.1221-8.   BACKGROUND: Renal fibrosis is common in progressive kidney disease. Transforming growth factors beta (TGF-beta) are important mediators of all types of fibrosis, including … Read More

Effect on Renal Function of Restoration of Euthyroidism in Hyperthyroid Cats with Iatrogenic Hypothyroidism

Williams T.L., Elliott J. and Syme H.M.   J Vet Intern Med, 2014. 28(4): p.1251-5.   BACKGROUND: Iatrogenic hypothyroidism is associated with an increased incidence of azotemia after treatment of hyperthyroidism, and decreased survival time in azotemic hyperthyroid cats. HYPOTHESIS: … Read More

Advances in the Treatment of Feline Hyperthyroidism: A Strategy to Slow the Progression of CKD

Peterson M. Conference Proceedings, (2014). American College of Veterinary Internal Medicine, Nashville: Hyperthyroidism and chronic kidney disease (CKD) are both common disorders in older cats. Therefore, it should not be surprising that both disorders frequently develop together in the same … Read More

Ultra-Low Doses of Radioiodine Are Highly Effective in Restoring Euthyroidism without Inducing Hypothyroidism in Most Cats with Milder Forms of Hyperthyroidism: 131 Cases

Peterson M.E. and Broome M.R. Conference Proceedings, (2014). American College of Veterinary Internal Medicine, Nashville: Radioactive iodine (131I) provides a simple, effective, and safe treatment for cats with hyperthyroidism. Ideally, treatment with a single dose of 131I restores euthyroidism without … Read More

Association between Urinary Vascular Endothelial Growth Factor Excretion and Chronic Kidney Disease in Hyperthyroid Cats

Williams T.L., Elliott J. and Syme H.M.   Res Vet Sci, 2014. 96(3): p.436-41.   Many hyperthyroid cats develop azotaemic chronic kidney disease (aCKD) following treatment, which has led to the hypothesis that hyperthyroidism might be detrimental to renal function. … Read More

Combined Assessment of Serum Free and Total T4 in a General Clinical Setting Seemingly Has Limited Potential in Improving Diagnostic Accuracy of Thyroid Dysfunction in Dogs and Cats

Rasmussen S.H., Andersen H.H. and Kjelgaard-Hansen M.   Vet Clin Pathol, 2014. 43(1): p.1-3. This letter is written to raise awareness that there may be no clear benefit in the combined measurement of serum total T4 (tT4) and free T4 … Read More

A Survey of Owners’ Perceptions and Experiences of Radioiodine Treatment of Feline Hyperthyroidism in the UK

Boland L.A., Murray J.K., Bovens C.P., et al.   J Feline Med Surg, 2014. 16(8): p.663-670.   The efficacy of radioiodine treatment of feline hyperthyroidism is well established; however, limited information is known about owners’ perceptions or experiences of radioiodine. … Read More

Comparison between Computed Tomography and 99mTc- Pertechnetate Scintigraphy Characteristics of the Thyroid Gland in Cats with Hyperthyroidism

Lautenschlaeger I.E., Hartmann A., Sicken J., et al. Vet Radiol Ultrasound, 2013. 54(6): p.666-673. Scintigraphy is currently the reference standard for diagnosing feline hyperthyroidism; however, computed tomography (CT) is more widely available in veterinary practice. The purposes of this prospective … Read More

Medical Management and Monitoring of the Hyperthyroid Cat, Survey of UK General Practitioners

Higgs P., Murray J. and Hibbert A. Conference Proceedings, (2013). British Small Animal Veterinary Congress: p.1-2 Feline hyperthyroidism is commonly managed with anti­thyroid medication, however, consensus regarding monitoring of treated cats is currently lacking. This study aimed to evaluate how … Read More

Amino Acid, Iodine, Selenium, and Coat Color Status among Hyperthyroid, Siamese, and Age-Matched Control Cats

Sabatino B.R., Rohrbach B.W., Armstrong P.J., et al. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 2013. 27(5): p.1049-55. BACKGROUND: Hyperthyroidism is common among older cats, but its pathogenesis remains poorly understood. Siamese and Himalayan cats … Read More

Investigation of the Pathophysiological Mechanism for Altered Calcium Homeostasis in Hyperthyroid Cats

Williams T.L., Elliott J., Berry J., et al.   The Journal of small animal practice, 2013. 54(7): p.367-73.   OBJECTIVE: To investigate possible pathophysiological mechanisms (reduced plasma calcitriol concentrations and/or presence of concurrent or masked chronic kidney disease) for hypocalcaemiain … Read More

Organohalogenated Contaminants in Domestic Cats’ Plasma in Relation to Spontaneous Acromegaly and Type 2 Diabetes Mellitus: A Clue for Endocrine Disruption in Humans?

Dirtu A.C., Niessen S.J., Jorens P.G., et al. Environment international, 2013. 57-58: p.60-7.   It was recently hypothesized that pets may serve as sentinels to explore human exposure to organohalogenated chemicals (OHCs) via indoor environments and adverse health effects. The … Read More

Use of L-Thyroxine Supplementation after Radioiodine Therapy Helps Blunt the Worsening of Azotemia in Hyperthyroid Cats with Pre-Existing Kidney Disease

Broome M.R. and Peterson M.E.   Conference Proceedings, (2013). American College of Veterinary Internal Medicine, Seattle: p.686   Hyperthyroidism develops in cats secondary to 1 or more autonomously functional thyroid adenomas. The progressive thy- rotoxicosis that ensues causes the chronic … Read More

An Online Survey to Determine Owner Experiences and Opinions on the Management of Their Hyperthyroid Cats Using Oral Anti-Thyroid Medications

Caney S.M. Journal of feline medicine and surgery, 2013. 15(6): p.494-502. Hyperthyroidism is the most common feline endocrinopathy. Treatment options comprise anti-thyroid medication, iodine-restricted diet, surgical thyroidectomy and radioiodine. One hundred and eleven owners of hyperthyroid cats completed a detailed … Read More

Evaluation of Thyroid-Stimulating Hormone, Total Thyroxine and Free Thyroxine Concentrations in 65 Hyperthyroid Cats Receiving Methimazole Therapy

Chciuk K., Behrend E.N., Martin L., et al.   Conference Proceedings, (2013). American College of Veterinary Internal Medicine:   Iatrogenic hypothyroidism following treatment of feline hyperthyroidism can have deleterious effects on renal function. Serum total thyroxine concentration (T4) is commonly … Read More

Investigation of the Pathophysiological Mechanism for Altered Calcium Homeostasis in Hyperthyroid Cats

Williams T., Elliott J. and Syme H.M.   Conference Proceedings, (2013). American College of Veterinary Internal Medicine, Seattle: p.686     Hyperthyroid cats are reported to have reduced blood ionised calcium concentrations (iCa) and elevated plasma parathyroid hormone (PTH) concentrations, … Read More

Sedation of Hyperthyroid Cats with Subcutaneous Administration of a Combination of Alfaxalone and Butorphanol

Ramoo S., Bradbury L., Anderson G., et al. Aust Vet J, 2013. 91(4): p.131-136. OBJECTIVE: To evaluate the sedative, respiratory and cardiovascular effects of subcutaneously administered alfaxalone and butorphanol in a group of hyperthyroid cats. DESIGN: A prospective, single-centre observational … Read More

Duration of T4 Suppression in Hyperthyroid Cats Treated Once and Twice Daily with Transdermal Methimazole

Boretti F.S., Sieber-Ruckstuhl N.S., Schafer S., et al. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, 2013. 27(2): p.377-81.   BACKGROUND: Transdermal methimazole is an acceptable alternative to oral treatment for hyperthyroid cats. There are, however, … Read More

Evaluation of Four Methods Used to Measure Plasma Insulin-Like Growth Factor 1 Concentrations in Healthy Cats and Cats with Diabetes Mellitus or Other Diseases

Tschuor F., Zini E., Schellenberg S., et al. Am J Vet Res, 2012. 73(12): p.1925-31.   Objective-To evaluate 4 methods used to measure plasma insulin-like growth factor (IGF) 1 concentrations in healthy cats and cats with diabetes mellitus or other … Read More

Surprising Bloodwork Results Following Treatment of 90 Hyperthyroid Cats with Radioactive Iodine-131 (131I)

Boshoven E.W. and Conway T.S. American College of Veterinary Radiologists, 2012. p.96.   Introduction/Purpose: Radioactive Iodine-131 (131I) has long been used for the treatment of patients with hyperthyroidism. Little information is available pertaining to the outcome of such treatments in … Read More

Calcium and Phosphate Homeostasis in Hyperthyroid Cats – Associations with Development of Azotaemia and Survival Time

Williams T.L., Elliott J. and Syme H.M. The Journal of small animal practice, 2012. 53(10): p.561-71.   OBJECTIVES: To evaluate calcium and phosphate homeostasis in hyperthyroid cats and determine if plasma parathyroid hormone and fibroblast growth factor-23 are associated with … Read More

Hyperthyroid Cats on Long-Term Medical Treatment Show a Progressive Increase in the Prevalence of Large Thyroid Tumors, Intrathoracic Thyroid Masses and Suspected Thyroid Carcinoma

Peterson M.E. and Broome M.R. Conference Proceedings, (2012). ECVIM, Maastricht, Netherlands:   Thyroid scintigraphy provides valuable information regarding both thyroid anatomy and physiology and plays an integral role in the diagnosis, staging, and management of feline thyroid disease. In this … Read More

Decabromobiphenyl, Polybrominated Diphenyl Ethers, and Brominated Phenolic Compounds in Serum of Cats Diagnosed with the Endocrine Disease Feline Hyperthyroidism

Norrgran J., Jones B., Lindquist N.G., et al. Arch Environ Contam Toxicol, 2012. 63(1): p.161-8.   The incidence of cats being diagnosed with feline hyperthyroidism (FH) has increased greatly since it was first described in 1979. The cause of FH … Read More

Controlled Level of Dietary Iodine Normalizes Serum Total Thyroxine in Cats with Naturally Occurring Hyperthyroidism

Yu S., Wedekind K.J., Burris P.A., et al. Conference Proceedings, (2011). American College of Veterinary Internal Medicine: Hyperthyroidism is a common disease in old cats. Excessive production of thyroid hormones is the hallmark of the disease. Three main treatments for … Read More

Amino Acid, Iodine, Selenium, and Coat Color Status among Hyperthyroid, Siamese, and Age- Matched Control Cats

Sabatino B.R., Kirk C.A., Rohrbach B.W., et al. Conference Proceedings, (2012). American College of Veterinary Internal Medicine, New Orleans: p.754-755   Hyperthyroidism is common among older cats, but its pathogenesis remains poorly understood. Siamese and Himalayan cats have a reduced … Read More

Restoration of Euthyroidism in Medically Treated Hyperthyroid Cats with Iatrogenic Hypothyroidism (IH) Improves Renal Function.

Williams T.L., Elliott J. and Syme H. Conference Proceedings, (2012). American College of Veterinary Internal Medicine, New Orleans: p.752-754   IH is reported to increase the incidence of azotemia in hyperthyroid cats following treatment. IH is also associated with a … Read More

The Efficacy and Safety of a Novel Lipophilic Formulation of Methimazole for the Once Daily Transdermal Treatment of Cats with Hyperthyroidism

Hill K.E., Gieseg M.A., Kingsbury D., et al. J Vet Intern Med, 2011. 25(6): p.1357-65.   BACKGROUND: Previous studies on transdermal methimazole have used pluronic lecithin organogel as the vehicle. This might not be the most suitable vehicle for a … Read More

Homeopathic and Integrative Treatment for Feline Hyperthyroidism – Four Cases (2006-2010)

Chapman S.F. Homeopathy, 2011. 100(4): p.270-4.   Hyperthyroidism is a frequent veterinary problem, particularly in elderly cats. Homeopathic treatment and other integrative modalities were provided for four hyperthyroid cats whose owners did not want conventional treatment. Symptomatic homeopathic treatment with … Read More

Accuracy of Serum Free Thyroxine Concentrations Determined by a New Veterinary Chemiluminscent Immunoassay in Euthyroid and Hyperthyroid Cats

Peterson M.E., Broome M.R. and Robertson J.E. Conference Proceedings, (2011). European College of Veterinary Internal Medicine, Sevilla, Spain: p.1   Free thyroxine (fT4) is the unbound biologically active fraction of total thyroxine (TT4). The pituitary-thyroid axis functions to maintain fT4 … Read More

Treatment of Hyperthyroidism and Concurrent Renal Disease: Is the “Tapazole Trial” Necessary?

Peterson M.E.   Conference Proceedings, (2011). American College of Veterinary Internal Medicine: p.101-103   Hyperthyroidism and chronic kidney disease (CKD) are both common disorders in older cats. Therefore, it should not be surprising that both disorders frequently develop together in … Read More

Iris Stages of Chronic Kidney Disease before and after Treatment with Radioiodine in Cats with Hyperthyroidism

Harley L.S., Peterson M.E., Langston C.E., et al. Conference Proceedings, (2011). American College of Veterinary Internal Medicine:   Although it is well established that concurrent chronic kidney disease (CKD) develops in about 30% of hyperthyroid cats, no one has reported … Read More

Gene Expression Analysis of Feline Thyroid Tissue and Blood from Cats with Evidence of Mild or Marked Hyperthyroidism Reveals Potential Molecular Causes of the Disease and Identifies Future Routes for Intervention

Melendez L. and Al-Murrani S. Conference Proceedings, (2011). American College of Veterinary Internal Medicine:   Hyperthyroidism is a disorder resulting from the excessive production and secretion of T4 and T3 by the thyroid gland. Although the disorder and its pathological … Read More

Controlled Level of Dietary Iodine Normalizes Serum Total Thyroxine in Cats with Naturally Occuring Hyperthyroidism

Shiguang Y., Wedekind K.J., Burris P.A., et al. Conference Proceedings, (2011). American College of Veterinary Internal Medicine, Denver:   Hyperthyroidism is a common disease in old cats. Excessive production of thyroid hormones is the hallmark of the disease. Three main … Read More

Changes in Plasma Fibroblast Growth Factor-23 (Fgf-23) Concentrations after Treatment of Hyperthyroidism (Hth) in Cats with Variable Renal Function

Williams T.L., Elliott J. and Syme H.M. Conference Proceedings, (2011). American College of Veterinary Internal Medicine:   FGF-23 is secreted by osteocytes and osteoblasts in response to hyperphosphatemia. FGF-23 enhances phosphaturia and is postu- lated to have a central role … Read More

Mild Hypercalcemia: An Indication to Select 4-Dimensional Computed Tomography Scan for Preoperative Localization of Parathyroid Adenomas

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Eichhorn-Wharry L.I., Carlin A.M. and Talpos G.B. Am J Surg, 2011. 201(3): p.334-8; discussion 338.   BACKGROUND: Technetium sestamibi scanning is the most accepted method of imaging used for preoperative localization of parathyroid adenomas. Four-dimensional computed tomography (4D-CT) scanning is … Read More

The Effect of Protease Inhibition on the Temporal Stability of Nt-Probnp in Feline Plasma at Room Temperature

Connolly D.J., Hezzell M.J., Fuentes V.L., et al. J Vet Cardiol, 2011. 13(1): p.13-9.   OBJECTIVES: To evaluate whether the addition of a protease inhibitor (PI) to feline plasma improves the temporal stability of N-terminal pro-B-type natriuretic peptide (NT-proBNP). ANIMALS, … Read More

Efficacy of Two Oral Anti-Thyroid Medications Used Once-Daily: A Laboratory Survey

Gallagher B., Mooney C. and Graham P. Conference Proceedings, (2011). British Small Animal Veterinary Association (BSAVA) Congress, Scientific Proceedings, Birmingham: p.457 Since 2008, there have been two licenced oral anti-thyroid medications for treating feline hyperthyroidism in the UK; Felimazole (Dechra … Read More

Serum Concentrations of Methimazole in Cats after a Single Oral Dose of Controlled-Release Carbimazole or Sugar-Coated Methimazole (Thiamazole)

Longhofer S., Martin-Jimenez T. and Soni-Gupta J. Vet Ther, 2010. 11(3): p.E1-7.   Methimazole (thiamazole) is an antithyroid drug commonly used to treat feline hyperthyroidism. It is routinely given twice daily. Carbimazole is a methimazole derivative that is rapidly metabolized … Read More

Association of Iatrogenic Hypothyroidism with Azotemia and Reduced Survival Time in Cats Treated for Hyperthyroidism

Williams T.L., Elliott J. and Syme H.M. J Vet Intern Med, 2010. 24: p.1086-1092.   Background: Iatrogenic hypothyroidism can occur after treatment of hyperthyroidism, and is correlated with a reduced glomerular filtration rate in humans and dogs. Hypothesis: Cats with … Read More

Investigation of Prognostic Factors for the Development of Renal Disease Following I-131 Therapy in Feline Hyperthyroidism

Morrison J., Jergens A., Deitz K., et al. Conference Proceedings, (2010). American College of Veterinary Internal Medicine, Anaheim: p.745   Hyperthyroidism is one of the most common endocrine disorders in middle aged to older cats. Renal disease may be masked … Read More

Evaluation of Activation of G Proteins in Response to Thyroid Stimulating Hormone in Thyroid Gland Cells from Euthyroid and Hyperthyroid Cats

Ward C.R., Windham W.R. and Dise D. Am J Vet Res, 2010. 71(6): p.643-8.   OBJECTIVE: To evaluate alterations in ligand-stimulated activity of G proteins in thyroid gland cells of hyperthyroid cats. SAMPLE POPULATION: Membranes of thyroid gland cells isolated … Read More

Clinical Efficacy and Safety of a Once-Daily Formulation of Carbimazole in Cats with Hyperthyroidism

Frenais R., Rosenberg D., Burgaud S., et al. J Small Anim Pract, 2009. 50(10): p.510-5.   OBJECTIVE: Evaluation of efficacy and safety of a novel controlled-release formulation of carbimazole in feline hyperthyroidism. METHODS: A multicentre, self-controlled study in 44 client-owned … Read More

Pharmacokinetics of L-Thyroxine after Oral Administration to Healthy Cats

Le Traon G., Burgaud S. and Horspool L.J. Conference Proceedings, (2009). European College of  Veterinary Internal Medicine – Companion Animals: p.269 Hyperthyroid cats may become (transiently) hypothyroid following 131I radiotherapy or surgical thyroidectomy. Oral supplementation with L-thyroxine (L-T4) may be … Read More

Optimal Testing for Thyroid Hormone Concentration after Treatment with Methimazole in Healthy and Hyperthyroid Cats

Rutland B.E., Nachreiner R.F. and Kruger J.M. J Vet Intern Med, 2009. 23(5): p.1025-30.   BACKGROUND: Methimazole suppresses thyroid hormone synthesis and is commonly used to treat feline hyperthyroidism. The degree of variation in thyroid hormone concentrations 24 hours after … Read More

Comparison of Plasma Clearance of Exogenous Creatinine, Exo-Iohexol, and Endo-Iohexol over a Range of Glomerular Filtration Rates Expected in Cats

Van Hoek I.M., Lefebvre H.P., Paepe D., et al. J Feline Med Surg, 2009. 11: p.1028-1030.   The study investigated plasma clearance of exogenous creatinine (PECCT), exo-iohexol (PexICT) and endo-iohexol (PenICT) in six healthy cats, four cats with chronic kidney … Read More

Partial Characterization of Feline Myeloperoxidase and Investigation of Its Potential Role as an Autoantigen in Hyperthyroid Cats

Pressler B.M., Robarge M.E. and Anderson K.I. Am J Vet Res, 2009. 70(7): p.869-78.   OBJECTIVE: To partially characterize the cDNA, amino acid sequence, and tertiary structure of feline myeloperoxidase, describe its cellular location in mature granulocytes, and determine whether … Read More

Hypertension in Hyperthyroid Cats: Prevalence, Incidence, and Predictors of Its Development

Morrow L.D., Adams V.J., Elliott J., et al. Conference Proceedings, (2009). American College of Veterinary Internal Medicine:   Hypertension and azotemic chronic kidney disease (aCKD) can be diagnosed concurrently with hyperthyroidism and have also been detected after initiation of treatment. … Read More

Short- and Long-Term Follow-up of Glomerular and Tubular Renal Markers of Kidney Function in Hyperthyroid Cats after Treatment with Radioiodine

Van Hoek I., Lefebvre H.P., Peremans K., et al. Domest Anim Endocrinol, 2009. 36(1): p.45-56.   Hyperthyroidism can mask co-existing chronic kidney disease (CKD). Previous studies showed that post-treatment renal azotemia can be predicted by pre-treatment assessment of glomerular filtration … Read More

Plasma Clearance of Exogenous Creatinine, Exo-Iohexol, and Endo-Iohexol in Hyperthyroid Cats before and after Treatment with Radioiodine

Van Hoek I., Lefebvre H.P., Kooistra H.S., et al. J Vet Intern Med, 2008. 22(4): p.879-85.   BACKGROUND: Glomerular filtration rate (GFR) can be measured by clearance methods of different markers showing discrepancies and different reproducibility in healthy cats. Studies … Read More

A Single Sample Method for Evaluating 51Chromium-Ethylene Diaminic Tetraacetic Acid Clearance in Normal and Hyperthyroid Cats

Vandermeulen E., Van Hoek I., De Sadeleer C., et al. J Vet Intern Med, 2008. 22(2): p.266-72.   BACKGROUND: Chronic kidney failure is frequently seen in middle-aged and elderly cats. 51Chromium-ethylene diaminic tetraacetic acid (51Cr-EDTA) clearance and single blood sample … Read More

Use of a Controlled-Release Formulation of Carbimazole for the Treatment of Feline Hyperthyroidism

Rosenburg D., Frenais R., Fornel-Thibaud P., et al. Conference Proceedings, (2008). Proceedings of the British Small Animal Veterinary Association Annual Congress: p.488   Carbimazole and its active metabolite methimazole are the standard medical treatment for hyperthyroidism in cats. Most effective … Read More

Plasma Clearance of Exogenous Creatinine, Exo-Iohexol and Endo-Iohexol in Healthy Cats, Cats with Hyperthyroidism and Cats with Chronic Kidney Disease.

Van Hoek I., Lefebvre H.P., Croubels S., et al. Conference Proceedings, (2008). American College of Veterinary Internal Medicine-PROC. 26TH ACVIM FORUM, San Antonia, TX: p.797 Measurement of glomerular filtration rate (GFR) in cats allows detection of a decreased kidney function … Read More

Investigation of Two Methods for Assessing Thyroid-Lobe Asymmetry During Pertechnetate Scintigraphy in Suspected Hyperthyroid Cats

Peter V. Scrivani N.L.D., Richard B. Page, Hollis N. Erb, Vet Radiol Ultrasound, 2007. 48(4): p.383-387.   Our aim was to investigate thyroid:thyroid (T:T) ratio and visual inspection for assessing thyroid-lobe asymmetry in suspected hyperthyroid cats. Although thyroid2013salivary asymmetry is … Read More

Brominated-Flame Retardants (BFRs) in Cats — Possible Linkage to Feline Hyperthyroidism?

Dye J.A. Conference Proceedings, (2007). American College of Veterinary Internal Medicine, Seattle:   Coincident with global introduction of BFRs into household consumer products nearly 30 years ago, hyperthyroidism in cats has increased considerably. The etiopathogenesis of feline hyperthyroidism remains unknown. … Read More

Short- And Long-Term Follow-Up of Hyperthyroid Cats Treated with Transdermal Methimazole

Boretti F.S., Sieber-Ruckstuhl N.S., Tschuor F., et al. Journal of Veterinary Internal Medicine, 2006. 20(6): p.1523-1524. During the last years alternative treatment of hyperthyroid cats using transdermal methimazole has increasingly been used. However, so far only one study evaluated treatment … Read More

Adenomatous Hyperplasia of the Thyroid Gland Is Related to TSH Concentration in Cats.

Kirkby R., Scase T., Wakeling J.E., et al. Journal of Veterinary Internal Medicine, 2006. 20(6): p.1522. In human patients, a well-defined syndrome of sub-clinical hyperthyroidism exists where thyroid hormone concentrations are within the reference range but thyroid stimulating hormone concentration … Read More

Expression and Purification of Feline Thyrotropin (fTSH): Immunological Detection and Bioactivity of Heteridimeric and Yoked Glycoproteins.

Rayalam S., Eizenstat L.D., Davis R.R., et al. Conference Proceedings, (2005). American College of Veterinary Internal Medicine, Baltimore:    One out of every three hundred cats is now diagnosed with hyperthyroidism. A diagnostic tool that can sensitively detect changes in … Read More

Accuracy of Increased Thyroid Activity During Pertechnetate Scintigraphy by Subcutaneous Injection for Diagnosing Hyperthyroidism in Cats

Page R.B., Scrivani P.V., Dykes N.L., et al. Vet Radiol Ultrasound, 2006. 47(2): p.206-11.   Our purpose was to determine the accuracy of increased thyroid activity for diagnosing hyperthyroidism in cats suspected of having that disease during pertechnetate scintigraphy using … Read More

Accuracy of Increased Thyroid Activity During Pertechnetate Scintigraphy by Subcutaneous Injection for Diagnosing Hyperthyroidism in Cats

Richard B. Page, Peter V. Scrivani, Nathan L. Dykes, et al. Vet Radiol Ultrasound, 2006. 47(2): p.206-211.   Our purpose was to determine the accuracy of increased thyroid activity for diagnosing hyperthyroidism in cats suspected of having that disease during … Read More

Relationship between Selected Echocardiographic Variables before and after Radioiodine Treatment in 91 Hyperthyroid Cats

Weichselbaum R.C., Feeney D.A. and Jessen C.R. Vet Radiol Ultrasound, 2005. 46(6): p.506-13.   Ninety-one spontaneously hyperthyroid cats were studied by two-dimensional and M-mode echocardiography with in a week before and 2-3 months following oral radioiodine administration. A statistical search … Read More

Seroreactivity to A-Type Retrovirus Proteins in a Subset of Cats with Hyperthyroidism

Sander D.M., Wolfsheimer K., Gallaher W.R., et al. Microsc Res Tech, 2005. 68(3-4): p.235-8.   The thyroid gland is afflicted in several endocrine, autoimmune, and malignant diseases. Previous studies detected immunoreactivity against proteins of a human intracisternal A-type retroviral particle … Read More

Thyroid to Salivary Ratios Determined by Technetium-99M Pertechnetate Imaging in Thirty-Two Euthyroid Cats

Henrikson T.D., Armbrust L.J., Hoskinson J.J., et al. Vet Radiol Ultrasound, 2005. 46(6): p.521-3.   Thyroid to salivary (TS) ratio is the most commonly used scintigraphic parameter for differentiating euthyroid and hyperthyroid cats. Studies to determine the normal TS ratio … Read More

Results of Diagnostic Investigations and Long-Term Outcome of 33 Dogs with Brain Infarction (2000–2004)

Garosi L., Mcconnell J.F., Platt S.R., et al. Journal of Veterinary Internal Medicine, 2005. 19(5): p.725-731.   Medical records of 33 dogs presented for acute onset, nonprogressive, intracranial dysfunction that had a magnetic resonance imaging diagnosis of brain infarction were … Read More

Ultrasonographic Evaluation of the Thyroid Gland in Healthy, Hypothyroid, and Euthyroid Golden Retrievers with Nonthyroidal Illness

Bromel C., Pollard R.E., Kass P.H., et al. J Vet Intern Med, 2005. 19(4): p.499-506.   Ultrasound evaluation of the thyroid gland was performed in healthy, hypothyroid, and euthyroid Golden Retriever dogs with nonthyroidal illness (NTI) to determine the diagnostic … Read More

G Proteins Show Normal Activation in Response to Thyroid Stimulating Hormone in Feline Hyperthyroid Cells.

Ward C.R., Dise D.G., Russell K.N., et al. Conference Proceedings, (2005). American College of Veterinary Internal Medicine, Baltimore: The pathogenesis of feline hyperthyroidism is not understood at the cellular or molecular level. Previous studies from our laboratory have identified a … Read More

Association of the Risk of Development of Hypothyroidism after Iodine 131 Treatment with the Pretreatment Pattern of Sodium Pertechnetate Tc 99m Uptake in the Thyroid Gland in Cats with Hyperthyroidism: 165 Cases (1990-2002)

Nykamp S.G., Dykes N.L., Zarfoss M.K., et al. J Am Vet Med Assoc, 2005. 226(10): p.1671-5.   OBJECTIVE: To assess whether the risk of development of hypothyroidism after treatment with iodine 131 (131I) was associated with the pattern of sodium … Read More

Effects of Methimazole on Thyroid Gland Uptake of 99MTC-Pertechnetate in 19 Hyperthyroid Cats

Anthony J. Fischetti, Wm Tod Drost, Stephen P. Dibartola, et al. Veterinary Radiology & Ultrasound, 2005. 46(3): p.267-272.   Nineteen cats with abnormally high serum T4 concentrations underwent thyroid scintigraphy using technetium-99m pertechnetate (99mTcO4) before and after 36±6 days of … Read More

Thyrotropin-Stimulated DNA Synthesis and Thyroglobulin Expression in Normal and Hyperthyroid Feline Thyrocytes in Monolayer Culture

Ward C.R., Achenbach S.E., Holt D., et al. Thyroid, 2005. 15(2): p.114-20.   Feline hyperthyroidism is a common, spontaneous disease in older cats that is similar clinically and histopathologically to human toxic multinodular goiter (TNG). In this study, the functional … Read More

The Role of Renin-Angiotensin-Aldosterone System (Raas) in the Development of Systemic Hypertension in Cats Treated for Hyperthyroidism

Jepson R.E., Elliott J. and Syme H.M. Conference Proceedings, (2005). American College of Veterinary Internal Medicine, Baltimore:   A proportion of hyperthyroid cats that have normal blood pressure at diagnosis become hypertensive following treatment. The aim of this study was … Read More

Feline Endocrinopathies

Gunn-Moore D. Vet Clin North Am Small Anim Pract, 2005. 35(1): p.171-210, vii.   Feline endocrinopathies (excluding diabetes mellitus) include hyperthyroidism, hypothyroidism, acromegaly, hyposomatotropism, diabetes insipidus, hyperadrenocorticism, primary sex hormone-secreting adrenal tumors, primary hyperaldosteronism, pheochromocytoma, hypoadrenocorticism, hyperparathyroidism, and hypoparathyroidism. Each … Read More