99mtc-Mdp Combined Blood Pool And Bone Phase Radionuclide Imaging In Papain-Injected Carpal Joints

Metcalf MR, Twardock AR, Sanecki RK.

Veterinary Radiology & Ultrasound 1985;26:106-116.

Scintigraphic changes, i.e., increased activity, were induced by 1% papain, dissolved in phosphate-buffered physiologic saline (pH 7.4), injected into one antebrachiocarpal joint in each of eight dogs. Scintigraphic evaluation was by the use of combined blood pool and bone phase scintigraphy of affected and normal carpi over a 28-day period. The qualitative and quantitative scintigraphic appearance in injected carpal joints were very similar in both blood pool and bone phases. The clinical use of combined blood pool and bone phase scintigraphy to diagnose early inflammatory joint changes appears limited.